The laboratory of Lev Fedorov investigates the important cross-talk between the Tuberous Sclerosis Complex (TSC) and the mTor pathway. By focusing on the Ras homolog enriched in brain (Rheb) gene using mouse genetics, important aspects of normal human development, birth defects and tumor predisposition syndromes (phakomatoses) can be understood. The intersection of these signaling cascades is also important to a number of other pediatric cancer to which targeted therapies are being developed. In addition to this research, Dr. Fedorov directs the OHSU Transgenic Mouse Models Shared Resource. To contact Dr. Fedorov about his exciting work, email him at fedorovl-at-ohsu.edu .
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